MODY Diabetes Gene Panel
Dipl.-Biol. Birgit Busse, Dipl.-Biol. Wolfgang Rupprecht
Maturity-onset diabetes of the young (MODY) is an autosomal dominant inherited group of clinically heterogenous types of diabetes which are not always insulin dependent. They are characterized by various disorders in the functions of beta cells in the pancreas. MODY is the most frequent form of monogenic diabetes and causes up to 5% of all diabetic diseases in Europe. The various forms of MODY diabetes have been classified according to their signs and symptoms as well as the respective genes affected by mutations. To date, there are 13 different types known, with MODY type 2 and 3 being the most frequently occurring forms.
All coding exons and their flanking intronic sequences from the genes in the MODY diabetes gene panel are analyzed either by Sanger sequencing or by next generation sequencing (NGS).